PEBC Exam Sample 2026–27: Practice Questions, Demo Tests & Preparation Guide

What is the PEBC Exam Sample ? 

The PEBC sample exam is a collection of practice questions that are designed to help candidates understand how the PEBC structure is determined. 

All of these questions are published by the Pharmacy Examining Board of Canada and explain the wording, style and competency-based approach used in actual exams. But there is another important point that many students miss. That is the official sample questions are not a full exam and do not represent the exact difficulty level, topic, difficulty level, topic distribution, and scoring style of the real examination. 

They just provide you with an example like how PEBC case knowledge and clinical decision-making. If you are preparing for the Evaluating examination or the Qualifying examination Part 1 (MCQ) then reviewing the official PEBC sample question is one of the smartest places to start.

Why are PEBC Exam Samples Important for Preparation? 

As we discussed with many international pharmacists. It is common in the educational system where exams focus heavily on memorisation. 

PEBC works differently.

The Canadian pharmacy licensing process mostly focuses on applying knowledge rather than recalling isolated facts. 

This is where PEBC practice tests become valuable. 

They help you: 

• To understand the PEBC question style.
• Learn how clinical scenarios are presented
• Improve critical thinking skills
• Build confidence before exam day
• Identify the knowledge gap
• Develop better time management. 

Just an example, the PEBC may provide a patient case and ask you to determine the most appropriate clinical action instead of asking you to simplify identifying a drug’s interaction. 

The more exposure you have to this question style then the more comfortable you feel during the actual exam.

PEBC Evaluating Exam sample questions PDF 

You can get the official sample questions through the examination reports of PEBC. 

These questions are mostly designed to express the format and the reasoning candidates can expect during the examination. 

The official PEBC MCQ sample questions cover multiple competency areas, which include: 

• The pharmaceutical science
• Pharmacy practice
• Behavioural, social and administrative pharmacy science. 

The official sample questions include the clinical scenarios involving infectious disease, diabetes, cardiovascular conditions, emergency, contraception, asthma management, PABC, pharmaceutical calculations and medication safety. 

You just need to remember that these questions are intended as examples only. They are not exact exam questions.

Here is a simple step-by-step process:

1. Visit the official PEBC website.
2. Go to the Pharmacists section.
3. Select the examination you are preparing for such as the PEBC Evaluating Examination or PEBC Qualifying Examination Part I (MCQ).
4. Open the Preparing for Examination section.
5. Look for the Sample Questions or Examination Resources page.
6. Download the available PDF document containing official sample questions.
7. Review the questions carefully and compare your answers with the answer key provided by PEBC.

PEBC Evaluating Exam Sample Questions

Biomedical Science

1.An oxidative reaction that converts a lipid into a free radical is called: 

1. Initiation
2. Synthesis
3. Termination
4. Complexation
5. Ionization

Correct Answer: a. 

2. Muscle contraction produced by the binding of calcium to calmodulin is a characteristic of:

1. cardiac muscle
2. striated muscle
3. smooth muscle
4. skeletal muscle
5. myosin and actin.

 Correct Answer: C

3. The spleen is located in which of the following abdominal regions?

1. Right hypochondriac region
2. Right lumbar region
3. Epigastric region
4. Left hypochondriac region
5. Left lumbar region

Correct Answer: D

4. Which of the following anatomical structures is most responsible for the production of male hormones?

1. Adrenal gland
2. Epididymis
3. Prostate
4. Testes
5. Vas deferens

Correct Answer: D

5. In the central nervous system, the internal capsule of the body connects which of the following body parts?

1. The left and right cerebral hemispheres
2. The left parietal and occipital lobes
3. The spinal cord and cerebellum
4. The cerebral cortex and medulla
5. The hippocampus and mammillary bodies

Correct Answer: D

6. Which of the following amino acid residues of proteins contains a side chain hydroxyl group that can be phosphorylated by protein kinases?

1. Glycine
2. Alanine
3. Serine
4. Cysteine
5. Isoleucine

 Correct Answer: C

Pharmaceutical Sciences

7. Which of the following medications induces an isoform of cytochrome P450?

1. Carbamazepine
2. Clarithromycin
3. Amiodarone
4. Metronidazole
5. Bosentan

 Correct Answer: A

8. Which of the following directly influences the in vitro physical stability of an oil-in-water emulsion in which the drug is incorporated in the dispersed phase?

1. Amount of preservative added
2. Molecular weight of the drug
3. Solubility of the emulsifier in water
4. Particle size of the internal phase
5. Type of suspending agent used

 Correct Answer: D

9. Abatacept acts by:

1. stimulating adenosine receptors.
2. binding to MHC Class II on B cells.
3. inhibiting B cell receptors.
4. activating T cell receptors.
5. binding CD80/86 on antigen-presenting cells.

 Correct Answer: E

10. Which of the following terms indicates a loss of moisture?

1. Deliquescence
2. Efflorescence
3. Hygroscopicity
4.  Polymorphism
5. Condensation

 Correct Answer: B

11. Factors that determine bioequivalence of two brands of a drug include the:

1.  taste of the preparations.
2. Physical appearance of the preparations.
3. pharmacokinetic parameters of the preparations.
4. cost of the preparations.
5. package size of the preparations.

 Correct Answer: C

12. Glycosaminoglycan and sulfated polysaccharide are structural descriptions of which of the following?

1. Heparin
2. Tobramycin
3. Doxorubicin
4. Cyclosporine
5. Hydrochlorothiazide

 Correct Answer: A

13. In some parenteral formulations, sodium metabisulphite is included as:

1. an antioxidant.
2. a chelator.30
3. a solubilizer.
4. a cosolvent.
5. an emulsifier.

Correct Answer: A

14. Which of the following medications is a cytochrome P450 inhibitor?

1. Phenytoin
2. Trastuzumab
3. Rituximab
4. Itraconazole
5. St. John’s wort

Correct Answer: D

15. How much NaCl is required to make 100 mL of isotonic 0.5% phenylephrine HCl solution? (NaCl equivalent of phenylephrine HCl is 0.32)

1.  100 mg
2. 300 mg
3. 500 mg
4. 740 mg
5. 900 mg

Correct Answer: D

16. Which of the following non-parenteral routes of administration yields the best bioavailability of biotechnology protein drugs?

1. Oral
2. Rectal
3. Ocular
4. Pulmonary
5. Transdermal

Correct Answer: D

Pharmacy Practice 

17. In a blood test for an older patient, what is the most probable physiological outcome consistent with the detection of normal 25(OH) vitamin D levels and undetectable levels of 1,25(OH)2 vitamin D?

1.  Hypertension
2. Osteoporosis
3. Hypothyroidism
4. Normal aging
5. Obesity

Correct Answer: B

18. Which of the following lists represents appropriate antibiotic options that are useful for treating Lyme disease?

1.       Doxycycline, amoxicillin, ceftriaxone
2.       Rifampin, cephalexin, ciprofloxacin
3.       Nitrofurantoin, trimethoprim, cloxacillin
4.       Norfloxacin, levofloxacin, moxifloxacin
5.       Sulfamethoxazole, isoniazid,  penicillin V

Correct Answer: A 

19. A mother presents at the pharmacy with her 8 year old daughter, DW, who has been experiencing a sore throat and nasal congestion for three days. The throat pain has progressively worsened over the last two days and DW reports that it “hurts to swallow”. The mother reports that DW’s forehead is “a bit warm to touch”, but she has not measured her temperature. In trying to rule out strep throat, which of the following is the most appropriate next step for the pharmacist?

1.       Ask the mother whether DW has had previous episodes of strep throat
2.       Ask the mother whether there is any swelling or tenderness of the lymph nodes in DW’s neck
3.       Examine DW’s face and neck for any evidence of a scarlatiniform rash
4.       Examine DW’s pharynx and tonsils for evidence of an exudate
5.       Perform a rapid antigen test in DW to detect the presence of group A streptococcus

Correct Answer: B

20. Which of the following is the most appropriate recommendation for calcium supplementation for a 70 year old postmenopausal female who gets approximately 250 mg of elemental calcium daily from dietary sources?

1.       Calcium citrate 300 mg po bid
2.       Calcium citrate 1000 mg po bid
3.       Calcium lactate 650 mg po bid
4.       Calcium carbonate 1250 mg po bid
5.       Calcium carbonate 1500 mg po daily

Correct Answer: D

21. An ophthalmic side effect that can occur with the use of sildenafil is:

1.       blue vision.
2.       corneal deposits.
3.       blepharospasm.
4.       pupil fixation.
5.       seeing flashing lights.

Correct Answer: A

Behavioural, Social and Administrative Pharmacy Sciences

22. The Patented Medicine Prices Review Board reports to the:

1.       provincial Ministers of Health.
2.       Public Health Agency of Canada.
3.       Canadian Parliament.
4.       Canadian Pharmacists Association.
5.       National Association of Pharmacy Regulatory Authorities.

Correct Answer: C

23. “Medically necessary” services are established in Canada by the:

1.   provincial governments.
2.   provincial drug plans.
3.   Canadian Medical Association.
4. Federal government.
5.   Royal College of Physicians and Surgeons of Canada.

Correct Answer: A

24. Vaccines are approved for use in Canada by the:

1.       Public Health Agency of Canada.
2.       Biologic and Radiopharmaceutical Drugs Directorate.
3.       Canadian Agency for Drugs and Technologies in Health.
4.       Therapeutic Products Directorate.
5.       National Advisory Committee on Immunization.

Correct Answer: B

25. In Canada, which of the following is responsible for initiating a recall of a potentially hazardous drug product?

1.       The Public Health Agency of Canada
2.       The drug product’s manufacturer
3.       Each provincial ministry of health
4.       Institute for Safe Medication Practices (ISMP) Canada
5.       Canadian Agency for Drugs and Technologies in Health (CADTH)

Correct Answer: B

26. The term ‘perspective’ in the context of a pharmacoeconomic study refers to the:

1.  source of funding for conducting the pharmacoeconomic analysis.
2. approach the researcher takes to analyze the research problem.
3. approach the researcher uses to limit confounding factors.
4. stakeholder whose interest is most represented in the study’s conclusions.
5. method used to facilitate communication of the study results in a journal publication.

Correct Answer: D

Source link of PEBC evaluating exam –  https://pebc.ca/wp-content/uploads/pdfs/Sample%20Question%20PDFs/Pharmacist%20Eval%20Exam%20Sample%20Questions%20-%20EN.pdf 

What Can You Learn From These PEBC Sample Questions? 

Most candidates notice several patterns after reviewing the official PEBC MCQ sample questions. 

• The question concepts are concept-based rather than fact-based. 
• Scientific and clinical reasoning is heavily tested. 
• So many questions required applying knowledge to a practical situation. 
• A strong understanding of fundamentals is very important. 

Why Do Many Candidates Use Structured PEBC Preparation Programmes? 

Self-study works well for some candidates. There are many international eligibility pharmacists who prefer structured preparation because it helps them to provide mentorship, accountability and organised learning. 

For example, the Elite Expertise PEBC preparation course is mostly designed for international pharmacists who want to become registered pharmacists in Canada. 

This program includes: 

• A structured six-month study plan
• Recorded and live classes
• Complete PEBC syllabus coverage.
• Canadian pharmacy law training
• Full-length PEBC mock exams
• One-on-one mentor support
• Performance tracking and feedback
• Access throughout the preparation period. 

The course of Elite expertise is led by experienced clinical pharmacists who are focused on helping students develop their clinical reasoning and exam techniques required for PEBC success.

Final Thoughts 

When you are preparing to become a registered pharmacist in Canada. The PEBC exam is one of the important examinations for you. 

To pass the exam, you need to follow the PEBC sample exam, and it is one of the most valuable starting points for any international graduate pharmacist. 

It gives you a little bit of an idea about how PEBC questions are written, how clinical reasoning is tested and what content spaces are assessed. 

But at the same time, don’t confuse yourself with the sample questions. Success in Canada and pharmacy examinations requires a combination of regular pharmacy PEBC practice tests, concept mastery, full-length PEBC mock exams and familiarity with the PEBC demo exam platform.